Evaluating the effects of socioeconomic status on stroke and bleeding risk scores and clinical events in patients on oral anticoagulant for new onset atrial fibrillation

Background The risk of thromboembolism and bleeding before initiation of oral anticoagulant (OAC) in atrial fibrillation patients is estimated by CHA(2)DS(2)-VASc and HAS-BLED scoring system, respectively. Patients' socioeconomic status (SES) could influence these risks, but its impact on the two risk scores' predictive performance with respect to clinical events remains unknown. Our objective was to determine if patient SES defined by area deprivation index (ADI), in conjunction with CHA(2)DS(2)-VASc and HAS-BLED scores, could guide oral anticoagulation therapy. Methods and findings The study cohort included newly diagnosed patients with AF who were treated with warfarin. The cohort was stratified by the time in therapeutic range of INR (TTR), ADI, CHA(2)DS(2)-VASc, and HAS-BLED risk scores. TTR and ischemic and bleeding events during the first year of therapy were compared across subpopulations. Among 7274 patients, those living in the two most deprived quintiles (ADI >= 60%) had a significantly higher risk of ischemic events and those in the most deprived quintile (ADI >= 80%) had a significantly increased risk of bleeding events. ADI significantly improved the predictive performance of CHA(2)DS(2)-VASc but not HAS-BLED risk scores. Conclusion ADI can predict increased risk for ischemic and bleeding events in the first year of warfarin therapy in patients with incident AF.

Automated summary

The study found that patient socioeconomic status (SES) defined by area deprivation index (ADI) can predict the risk of ischemic and bleeding events in atrial fibrillation patients undergoing warfarin therapy in the first year. ADI significantly improved the predictive performance of the CHA(2)DS(2)-VASc risk score, but did not affect the HAS-BLED risk score.