Journal
PLANTA MEDICA
Volume 88, Issue 6, Pages 455-465Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1449-2642
Keywords
Chloranthus elatior; Chloranthaceae; sesquiterpenes; sesquiterpene dimers; diterpenes; hDHODH inhibition
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Funding
- National Natural Science Foundation of China [81603279]
- National Science and Technology Project of China [2018ZX09731-016]
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A new sesquiterpene, a new sesquiterpene dimer, and two new diterpenes were isolated from Chloranthus elatior, along with 51 known compounds. The structures of the new compounds were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. The compounds were tested for their anti-hDHODH activity, with two compounds showing the most activity.
A new sesquiterpene, chlorantholide G ( 1 ), a new sesquiterpene dimer, elatiolactone ( 2 ), and 2 new diterpenes, elatiorlabdane B ( 3 ) and elatiorlabdane C ( 4 ), together with 51 known compounds, were isolated from the aerial parts of Chloranthus elatior . The new structures including their absolute configurations were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. All isolated compounds were tested for their anti-hDHODH activity. (4 S ,6 R )-4-hydroxy-6-isopropyl-3-methylcyclohex-2-enone ( 5 ) and (4 S ,5 R ,9 S ,10 R )-8(17),12,14-labdatrien-18-oic acid ( 29 ) were the most active compounds with IC (50) values of 18.7 and 30.7 mu M, respectively.
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