Journal
PLANT FOODS FOR HUMAN NUTRITION
Volume 76, Issue 2, Pages 189-195Publisher
SPRINGER
DOI: 10.1007/s11130-021-00891-x
Keywords
Passiflora edulis; Cardioprotection; ISO; Antioxidant activity
Funding
- UGC [F.4-2/2006 (BSR)/BL/14-15/0480]
- UGC-BSR [4-5(11)/2019(BSR)]
- University Grants Commission (UGC), New Delhi
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PE juice demonstrated cardioprotective effects in the rat model of myocardial infarction, mitigating cardiac injury induced by ISO.
The common reason for mortality globally is myocardial infarction. The study aimed to evaluate Passiflora edulis (PE) fruit juice potential in the experimental isoproterenol (ISO) treated rat model to manage myocardial injury. ISO (20 mg/100 g body weight) treated rats showed a significant increment in serum marker enzymes lactate dehydrogenase (LDH) and creatinine kinase (CK), serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), serum alkaline phosphatase (ALP) and serum acid phosphatase (ACP) activity. Besides, phosphorus and calcium, serum cholesterol, and triglyceride levels (TG) were high in ISO groups. A significant decline in antioxidant activity and histopathological alteration was observed in ISO treated groups. PE juice pre-treatment (2 ml/kg) for 28 days and ISO treatment on the 29th and 30th days showed a protective effect on distorted biochemical and histopathologic parameters compared with reference drug metoprolol. These findings indicate the cardioprotective effect of PE juice on ISO-induced myocardial infracted rats.
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