4.7 Article

Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

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Summary: The SARS-CoV-2 virus has caused a global pandemic with over 1.2 million confirmed cases and nearly 65,000 deaths, leading to a search for effective treatments. Clinical trials are being conducted on antiviral drugs, but the lack of approved treatments highlights the need for novel compounds. Andrographolide from Andrographis paniculata shows promise as an inhibitor for SARS-CoV-2 main protease, with in silico studies suggesting good solubility, pharmacodynamics properties, and target accuracy.

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