Journal
PHYSIOLOGICAL MEASUREMENT
Volume 42, Issue 4, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1361-6579/abf1b1
Keywords
Cardiovascular system; Apparent compliance; Input Impedance; Fractional order capacitor; Arterial stiffness; fractional calculus
Categories
Funding
- King Abdullah University of Science and Technology (KAUST) [BAS/1/162701-01]
Ask authors/readers for more resources
The study introduces novel lumped-parameter equivalent circuit models for apparent arterial compliance using fractional-order capacitors, showing potential in capturing elastic and viscous properties. Results demonstrate a good fit with in-silico data of over 4000 subjects, and strong correlations between fractional-order parameter estimates and central hemodynamic determinants as well as pulse-wave velocity indexes. Therefore, the fractional-order-based paradigm for arterial compliance presents notable potential as an alternative tool in the analysis of arterial stiffness.
Objective. Recent studies have demonstrated the advantages of fractional-order calculus tools for probing the viscoelastic properties of collagenous tissue, characterizing the arterial blood flow and red cell membrane mechanics, and modeling the aortic valve cusp. In this article, we present novel lumped-parameter equivalent circuit models for apparent arterial compliance using a fractional-order capacitor (FOC). FOCs, which generalize capacitors and resistors, display a fractional-order behavior that can capture both elastic and viscous properties through a power-law formulation. Approach. The proposed framework describes the dynamic relationship between the blood-pressure input and the blood volume, using linear fractional-order differential equations. Main results. The results show that the proposed models present a reasonable fit with the in-silico data of more than 4000 subjects. Additionally, strong correlations have been identified between the fractional-order parameter estimates and the central hemodynamic determinants as well as the pulse-wave velocity indexes. Significance. Therefore, the fractional-order-based paradigm for arterial compliance shows notable potential as an alternative tool in the analysis of arterial stiffness.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available