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JOURNAL OF ALZHEIMERS DISEASE (2014)
Screening and identification of neuroprotective compounds relevant to Alzheimer's disease from medicinal plants of S. Tome e Principe
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Neuroprotective effect of steroidal alkaloids on glutamate-induced toxicity by preserving mitochondrial membrane potential and reducing oxidative stress
Marcos Taveira et al.
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Cudarflavone B Provides Neuroprotection against Glutamate-Induced Mouse Hippocampal HT22 Cell Damage through the Nrf2 and PI3K/Akt Signaling Pathways
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MOLECULES (2014)
Spongionella Secondary Metabolites Protect Mitochondrial Function in Cortical Neurons against Oxidative Stress
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Daphnetin, a Natural Coumarin Derivative, Provides the Neuroprotection Against Glutamate-Induced Toxicity in HT22 Cells and Ischemic Brain Injury
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NEUROCHEMICAL RESEARCH (2014)
Curcumin Prevents Cerebral Ischemia Reperfusion Injury Via Increase of Mitochondrial Biogenesis
Li Liu et al.
NEUROCHEMICAL RESEARCH (2014)
Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats
Milind Geed et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2014)
Andrographolide, a major component of Andrographis paniculata leaves, has the neuroprotective effects on glutamate-induced HT22 cell death
Eun-Ju Yang et al.
JOURNAL OF FUNCTIONAL FOODS (2014)
Glutathione and mitochondria
Vicent Ribas et al.
FRONTIERS IN PHARMACOLOGY (2014)
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway
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AGING CELL (2013)
Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain
Antonio Currais et al.
ANTIOXIDANTS & REDOX SIGNALING (2013)
Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease
Heather Mortiboys et al.
BRAIN (2013)
Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice
N. Rajasekar et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells
Eun-Ju Yang et al.
FOOD AND CHEMICAL TOXICOLOGY (2013)
Glutathione metabolism and Parkinson's disease
Michelle Smeyne et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
PGC-1α, mitochondrial dysfunction, and Huntington's disease
Ashu Johri et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Tetrahydrohyperforin Induces Mitochondrial Dynamics and Prevents Mitochondrial Ca2+ Overload after Aβ and Aβ-AChE Complex Challenge in Rat Hippocampal Neurons
Juan M. Zolezzi et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration
Xing Guo et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
(M)- and (P)-Bicelaphanol A, Dimeric Trinorditerpenes with Promising Neuroprotective Activity from Celastrus orbiculatus
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Pharmacological approaches to restore mitochondrial function
Penelope A. Andreux et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8
Gunter P. Eckert et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
Yong-Ning Deng et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
RESVERATROL PROTECTS SPINAL CORD DORSAL COLUMN FROM HYPOXIC INJURY BY ACTIVATING NRF-2
V. Kesherwani et al.
NEUROSCIENCE (2013)
Neuroprotective effects of liquiritigenin isolated from licorice roots on glutamate-induced apoptosis in hippocampal neuronal cells
Eun-Ju Yang et al.
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Mitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures
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PLOS ONE (2013)
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Ilse S. Pienaar et al.
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Sudhakar Raja Subramaniam et al.
PROGRESS IN NEUROBIOLOGY (2013)
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TRENDS IN CELL BIOLOGY (2013)
The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
Marguerite Prior et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells
Min-fang Xu et al.
ACTA PHARMACOLOGICA SINICA (2012)
Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction
Eun-Ju Yang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon et al.
CELL (2012)
Mitochondria: In Sickness and in Health
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CELL (2012)
Shaping the role of mitochondria in the pathogenesis of Huntington's disease
Veronica Costa et al.
EMBO JOURNAL (2012)
Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria
Xiao-xiu Li et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Animal models of Parkinson's disease
Fabio Blandini et al.
FEBS JOURNAL (2012)
Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration
Maria Moran et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
An alternative approach to drug discovery for Alzheimer's disease dementia
David Schubert et al.
FUTURE MEDICINAL CHEMISTRY (2012)
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
Ulziibat P. Shirendeb et al.
HUMAN MOLECULAR GENETICS (2012)
Decreased Accumulation of Subcellular Amyloid-β with Improved Mitochondrial Function Mediates the Neuroprotective Effect of Huperzine A
Ling Yang et al.
JOURNAL OF ALZHEIMERS DISEASE (2012)
trans-(-)-ε-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease
Jinrong Fu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Chemical Modification of the Multitarget Neuroprotective Compound Fisetin
Chandramouli Chiruta et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Synthesis and Biological Activities of N-(3-Carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues
Manikandadas M. Madathil et al.
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Flavone potently stimulates an apical transporter for flavonoids in human intestinal Caco-2 cells
Barbara Lies et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2012)
Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice
Gui-Shan Liu et al.
LIFE SCIENCES (2012)
Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
Gang Zhao et al.
NEUROBIOLOGY OF AGING (2012)
Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease
Nian Xiong et al.
NEUROBIOLOGY OF AGING (2012)
Mitochondrial Fission, Fusion, and Stress
Richard J. Youle et al.
SCIENCE (2012)
Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction, and Matrix Metalloproteinase-9 Induction After Focal Cerebral Ischemia
Ki Yong Lee et al.
STROKE (2012)
Mitochondrial Effects of Plant-Made Compounds
Lucia Biasutto et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection
Gregor Zuendorf et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
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CELL METABOLISM (2011)
Astaxanthin protects against MPTP/MPP plus -induced mitochondrial dysfunction and ROS production in vivo and in vitro
Dae-Hee Lee et al.
FOOD AND CHEMICAL TOXICOLOGY (2011)
First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics
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Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease (vol 10, pg 187, 2011)
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LANCET NEUROLOGY (2011)
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Wenjun Song et al.
NATURE MEDICINE (2011)
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David C. Swinney et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23.5 cells
Kai Zhang et al.
NEUROPHARMACOLOGY (2011)
Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity
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NEUROSCIENCE LETTERS (2011)
Neuroprotective effects of tenuigenin in a SH-SY5Y cell model with 6-OHDA-induced injury
Zhigang Liang et al.
NEUROSCIENCE LETTERS (2011)
Neuroprotective Diarylheptanoids from the Leaves and Twigs of Juglans sinensis against Glutamate-Induced Toxicity in HT22 Cells
Heejung Yang et al.
PLANTA MEDICA (2011)
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Qi Chen et al.
PLOS ONE (2011)
Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
Dimitrios Kapogiannis et al.
LANCET NEUROLOGY (2011)
Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial-Lysosomal Axis Theory of Aging
Alexei Terman et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells
Anna Atlante et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
Veronica Costa et al.
EMBO MOLECULAR MEDICINE (2010)
Severe Motor Neuron Degeneration in the Spinal Cord of the Tg2576 Mouse Model of Alzheimer Disease
Ji-Seon Seo et al.
JOURNAL OF ALZHEIMERS DISEASE (2010)
Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes
Mei-Jie Jou et al.
JOURNAL OF PINEAL RESEARCH (2010)
Long-term melatonin administration protects brain mitochondria from aging
Miguel Carretero et al.
JOURNAL OF PINEAL RESEARCH (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
The MitoPark Mouse - An animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons
Mats Ekstrand et al.
PARKINSONISM & RELATED DISORDERS (2009)
Dystrophic neurites of senile plaques in Alzheimer's disease are deficient in cytochrome c oxidase
Esther Perez-Gracia et al.
ACTA NEUROPATHOLOGICA (2008)
A broadly neuroprotective derivative of curcumin
Yuanbin Liu et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Isoflavones promote mitochondrial biogenesis
Kyle A. Rasbach et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Complex I is the major site of mitochondrial superoxide production by paraquat
Helena M. Cocheme et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance
Manus W. Ward et al.
JOURNAL OF NEUROSCIENCE (2007)
Melatonin prevents glutamate-induced oxytosis in the HT22 mouse hippocampal cell line through an antioxidant effect specifically targeting mitochondria
Federico Herrera et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Mats I. Ekstrand et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
Pamela Maher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
NATURE (2006)
Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Libin Cui et al.
CELL (2006)
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
Latha Devi et al.
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Mitochondria: Dynamic organelles in disease, aging, and development
David C. Chan
CELL (2006)
Therapeutic potential of resveratrol: the in vivo evidence
Joseph A. Baur et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Metabolic control through the PGC-1 family of transcription coactivators
JD Lin et al.
CELL METABOLISM (2005)
Glucose metabolism and Alzheimer's disease
D Schubert
AGEING RESEARCH REVIEWS (2005)
Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals
I Sipos et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
D Blum et al.
PROGRESS IN NEUROBIOLOGY (2001)
Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms
K Ishige et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
R Betarbet et al.
NATURE NEUROSCIENCE (2000)