4.7 Review

The hormetic dose-response mechanism: Nrf2 activation

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis

Edward J. Calabrese et al.

Summary: Sulforaphane (SFN) induces hormetic dose responses through Nrf2 activation, reducing human-related pathologies and enhancing stem cell proliferation. SFN shows potential utility in cancer treatment and plays a role in limiting age-related damage and disease progression.

PHARMACOLOGICAL RESEARCH (2021)

Review Cell Biology

Demonstrated hormetic mechanisms putatively subserve riluzole-induced effects in neuroprotection against amyotrophic lateral sclerosis (ALS): Implications for research and clinical practice

Edward J. Calabrese et al.

Summary: This study provides evidence that riluzole, an FDA-approved treatment for ALS, displays hormetic biphasic dose responses like many neuroprotective agents. These findings are important for the experimental study and clinical treatment of ALS.

AGEING RESEARCH REVIEWS (2021)

Article Pharmacology & Pharmacy

Does Green Tea Induce Hormesis?

Edward J. Calabrese et al.

DOSE-RESPONSE (2020)

Article Biochemistry & Molecular Biology

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells

Luoyao Yang et al.

REDOX BIOLOGY (2020)

Article Chemistry, Multidisciplinary

Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway

Shi-feng Chu et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Medicine, Research & Experimental

Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway

Guizhen Zheng et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Environmental Sciences

Estimating the range of the maximum hormetic stimulatory response

Edward J. Calabrese et al.

ENVIRONMENTAL RESEARCH (2019)

Article Toxicology

Effect of fluoride on PERK-Nrf2 signaling pathway in mouse ameloblasts

X. Zhou et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2019)

Article Medicine, Research & Experimental

Methylene blue elicits non-genotoxic H2O2 production and protects brain mitochondria from rotenone toxicity

Artem P. Gureev et al.

JOURNAL OF APPLIED BIOMEDICINE (2019)

Article Biochemistry & Molecular Biology

Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis

Ai-Ling Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Physiology

Ischaemic and hypoxic conditioning: potential for protection of vital organs

Justin D. Sprick et al.

EXPERIMENTAL PHYSIOLOGY (2019)

Editorial Material Pharmacology & Pharmacy

Building Biological Shields via Hormesis

Edward J. Calabrese et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Carbon Monoxide Ameliorates 6-Hydroxydopamine-Induced Cell Death in C6 Glioma Cells

Hyewon Moon et al.

BIOMOLECULES & THERAPEUTICS (2018)

Article Pharmacology & Pharmacy

Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons

Yasuhiko Izumi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

Article Biotechnology & Applied Microbiology

Early antioxidant responses via the concerted activation of NF-κB and Nrf2 characterize the gamma-radiation-induced adaptive response in quiescent human peripheral blood mononuclear cells

Neha Paraswani et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2018)

Article Nutrition & Dietetics

Metabolic Responses in Endothelial Cells Following Exposure to Ketone Bodies

Erika Meroni et al.

NUTRIENTS (2018)

Review Pharmacology & Pharmacy

Enhancing and Extending Biological Performance and Resilience

Rehana K. Leak et al.

DOSE-RESPONSE (2018)

Article Pharmacology & Pharmacy

The effects of Nrf2 knockout on regulation of benzene-induced mouse hematotoxicity

Huiyao Li et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Nrf2 Signaling Elicits a Neuroprotective Role Against PFOS-mediated Oxidative Damage and Apoptosis

Pingping Sun et al.

NEUROCHEMICAL RESEARCH (2018)

Review Pharmacology & Pharmacy

Hormesis mediates dose-sensitive shifts in macrophage activation patterns

Edward J. Calabrese et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Upregulation of NRF2 through autophagy/ERK 1/2 ameliorates ionizing radiation induced cell death of human osteosarcoma U-2 OS

Ni Chen et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2017)

Article Toxicology

JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2

X. Zhao et al.

TOXICOLOGY LETTERS (2017)

Article Biochemistry & Molecular Biology

Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

Shikha Prasad et al.

REDOX BIOLOGY (2017)

Review Geriatrics & Gerontology

How does hormesis impact biology, toxicology, and medicine?

Edward J. Calabrese et al.

NPJ AGING AND MECHANISMS OF DISEASE (2017)

Article Pharmacology & Pharmacy

Low-Dose Dose-Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells

Kenneth T. Bogen

DOSE-RESPONSE (2017)

Review Biochemistry & Molecular Biology

Nrf2 signaling pathway: Pivotal roles in inflammation

Syed Minhaj Uddin Ahmed et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Review Pharmacology & Pharmacy

Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations

Edward J. Calabrese

PHARMACOLOGICAL RESEARCH (2016)

Article Psychology, Biological

How sodium arsenite improve amyloid β-induced memory deficit?

Ehsan Nassireslami et al.

PHYSIOLOGY & BEHAVIOR (2016)

Article Biochemistry & Molecular Biology

A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes

Gobinath Shanmugam et al.

REDOX BIOLOGY (2016)

Article Biochemistry & Molecular Biology

ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell

Ni Chen et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2015)

Article Biochemistry & Molecular Biology

Mechanism of Dose-Dependent Regulation of UBE1L by Polyphenols in Human Bronchial Epithelial Cells

Apei Jiang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept

Mireille M. J. P. E. Sthijns et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Engineering, Environmental

lodoacetic Acid Activates Nrf2-Mediated Antioxidant Response in Vitro and in Vivo

Shu Wang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)

Article Biochemistry & Molecular Biology

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

Cliona Stack et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Neuroprotective Effects of Sulforaphane on Cholinergic Neurons in Mice with Alzheimer's Disease-Like Lesions

Rui Zhang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Biochemistry & Molecular Biology

Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model

Hyunjin Vincent Kim et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2013)

Article Chemistry, Medicinal

Bisphenol A Activates the Nrf1/2-Antioxidant Response Element Pathway in HEK 293 Cells

Nikolai L. Chepelev et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2013)

Review Toxicology

Hormetic mechanisms

Edward J. Calabrese

CRITICAL REVIEWS IN TOXICOLOGY (2013)

Review Cell Biology

Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases

Andrea Tarozzi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)

Article Biochemistry & Molecular Biology

Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death?

Weimin Chen et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Biochemistry & Molecular Biology

Age-related cataracts: Homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection

Rajan Elanchezhian et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2012)

Article Biochemistry & Molecular Biology

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

Andrew M. Pickering et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation

Sang Bum Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Neurosciences

Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue

Julio C. Rojas et al.

PROGRESS IN NEUROBIOLOGY (2012)

Review Geriatrics & Gerontology

Lest we forget you - methylene blue ...

R. Heiner Schirmer et al.

NEUROBIOLOGY OF AGING (2011)

Article Biochemistry & Molecular Biology

Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity

Hirokazu Hara et al.

NEUROCHEMISTRY INTERNATIONAL (2011)

Article Medicine, Legal

The hormesis database: The occurrence of hormetic dose responses in the toxicological literature

Edward J. Calabrese et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2011)

Review Biochemistry & Molecular Biology

When NRF2 Talks, Who's Listening?

Nobunao Wakabayashi et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Review Oncology

Nrf2: friend or foe for chemoprevention?

Thomas W. Kensler et al.

CARCINOGENESIS (2010)

Article Multidisciplinary Sciences

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

Pei-Chun Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Toxicology

Methylmercury Toxicity and Nrf2-dependent Detoxification in Astrocytes

Ling Wang et al.

TOXICOLOGICAL SCIENCES (2009)

Article Pharmacology & Pharmacy

Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells

Jun Chen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

Article Pharmacology & Pharmacy

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages

Courtney G. Woods et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

Review Environmental Sciences

Hormesis: Why it is important to toxicology and toxicologists

Edward J. Calabrese

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2008)

Article Pharmacology & Pharmacy

Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid

Jingbo Pi et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2008)

Article Neurosciences

Nrf2--mediated protection against 6-hydroxydopamine

Rebekah J. Jakel et al.

BRAIN RESEARCH (2007)

Article Clinical Neurology

Expression of Nrf2 in neurodegenerative diseases

Chenere P. Ramsey et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)

Article Neurosciences

In vivo modulation of the Parkinsonian phenotype by Nrf2

Neal C. Burton et al.

NEUROTOXICOLOGY (2006)

Review Biochemistry & Molecular Biology

Nrf2-Keap1 defines a physiologically important stress response mechanism

H Motohashi et al.

TRENDS IN MOLECULAR MEDICINE (2004)

Article Toxicology

Defining hormesis

EJ Calabrese et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2002)

Article Toxicology

Overcompensation stimulation: A mechanism for hormetic effects

EJ Calabrese

CRITICAL REVIEWS IN TOXICOLOGY (2001)