Journal
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
Volume 26, Issue 5, Pages 559-575Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10837450.2021.1901915
Keywords
Machine design; Loss-in-Weight feeder; auger dosing; proof of concept; mass flow rate; powder dosing
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In this study, a vertical Loss-in-Weights feeder prototype was experimentally validated and functionally designed, demonstrating a semi-automated dosing machine for various powders. The prototype was verified through experimental sensitivity analysis and testing, confirming the design concept.
Loss-in-Weights (LiW) feeders are commonly oriented in a horizontal way. In this work, an experimental proof of concept, including mechanical and electrical design, construction, and operation, of a vertical LiW feeder prototype is performed. In a systematic design process, based on functional design specifications, the semi-automated vertical LiW feeder for dosing a wide range of powders, especially cohesive ones, is developed. The new dosing machine is assessed with regard to a number of key features such as high dosing accuracy, first-in-first-out powder discharge, easily interchange of the powder container, and flexibility in controlling the speed of the auger and stirrer motors independently. An experimental sensitivity analysis to study the functionality of the dosing machine and to investigate the weight variability of the weighing platform, i.e. mass flow rate, and quantity of dosed mass, is carried out. The results of the sensitivity analysis and the powder dosing tests of five diverse powders using different auger and stirrer geometries verified the proof of concept prototype.
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