Journal
PEDIATRIC BLOOD & CANCER
Volume 68, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/pbc.29043
Keywords
chemotherapy; childhood cancer survivorship; esophageal disease; esophageal stricture; radiation
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Among childhood cancer survivors, the prevalence of esophageal strictures is 2.0%, which is significantly higher than in siblings. Risk factors for esophageal stricture include diagnosis of Hodgkin lymphoma, higher chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. Although rare, survivors are at risk for therapy-related esophageal strictures.
There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to determine the prevalence and risk factors for esophageal strictures. Prevalence among survivors was 2.0% (95% confidence interval [CI]: 1.8-2.2%), representing a 7.6-fold increased risk compared to siblings. Factors significantly associated with risk of esophageal stricture included diagnosis of Hodgkin lymphoma, greater chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. While uncommon, survivors are at risk for therapy-related esophageal strictures.
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