BCYRN1: An oncogenic lncRNA in diverse cancers

Brain cytoplasmic 200 (BC200) or alternatively named as brain cytoplasmic RNA 1 (BCYRN1) is a long noncoding RNA (lncRNA) primarily identified in the neurons. In addition to its participation in the pathogenesis of neurodegenerative disorders, it partake in the carcinogenesis process. Numerous in vitro studies have reported elevation of expression of BCYRN1 in cancer cell lines. Short hairpin-RNA-mediated silencing of BCYRN1 has attenuated growth of tumors in the animal models. Independent studies in esophageal squamous cell cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma and non-small cell lung cancer have demonstrated association between elevated BCYRN1 levels and poor survival of patients. Taken together, BCYRN1 is an appropriate candidate for targeted therapies in the field of cancer.

Automated summary

BCYRN1, a long noncoding RNA primarily found in neurons, not only plays a role in the pathogenesis of neurodegenerative disorders, but also in the process of carcinogenesis. Studies have shown elevated levels of BCYRN1 in various cancer types are associated with poor patient survival, making it a potential candidate for targeted therapy in the field of cancer.