Journal
ORGANOMETALLICS
Volume 40, Issue 7, Pages 880-889Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.0c00800
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Funding
- National Natural Science Foundation of China [81860315, 21602078]
- China Postdoctoral Science Foundation [2018M643775]
- Pearl River Talent Program of Guangdong Province (Youth topnotch talent) [2017GC010302]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011743]
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A highly efficient palladium-catalyzed cascade annulation has been developed to access various benzo[c]cinnoline derivatives at 80 degrees C, with a pyridine-type ligand improving the reaction efficiency to yield up to 94%. This novel approach offers a one-pot dual C-H activation strategy with good functional group tolerance and easy conversion into cinnoline derivatives.
A highly efficient palladium-catalyzed cascade annulation of pyrazolones and aryl iodides to access various benzo[c]cinnoline derivatives has been achieved at 80 degrees C. A pyridine-type ligand could improve the reaction efficiency under current reaction conditions, giving a higher product yield up to 94%. This novel approach provided a one-pot dual C-H activation strategy with good functional group tolerance, such as halogen, methoxy, nitro, ester, phenol, and so forth. The product could readily convert into cinnoline derivatives.
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