Convergent Palladium-Catalyzed Stereospecific Arginine Glycosylation Using Glycals

A stereospecific convergent peptide arginine glycosylation method is reported for the first time. A recently discovered arginine glycosylation invigorated the interests of arginine modification, which has been challenging, because of the inertness of the guanidino side chain. The approach renders the arginine glycoside construction convergently. Catalyzed by palladium complex, glycals modify arginine guanidino groups in one step with high functional group tolerance at ambient temperature. The glycosylated products may be converted to glycopeptide analogues in few steps.

Automated summary

This method allows effective arginine glycosylation, catalyzed by a palladium complex, which can be achieved in one step at room temperature with high functional group tolerance, facilitating the preparation of glycopeptide analogues.