Journal
ORGANIC LETTERS
Volume 23, Issue 8, Pages 3211-3215Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00951
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- City University of Hong Kong [7200579, 9610412]
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Heterologous expression in the fungus Aspergillus funiculosus CBS 116.56 led to the discovery of four new meroterpenoids, funiculolides A-D, with funiculolide D featuring an unusual spirocyclopentanone moiety synthesized by the iron and alpha-ketoglutarate-dependent dioxygenase FncG.
Heterologous expression of a cryptic gene cluster in the fungus Aspergillus funiculosus CBS 116.56 led to the discovery of four new meroterpenoids, funiculolides A-D (1-4), derived from the aromatic polyketide 5-methylorsellinic acid (5-MOA). Intriguingly, funiculolide D (4), the apparent end product of the pathway, harbors an unusual spirocyclopentanone moiety, which is synthesized by the oxidative rearrangement catalyzed by the ferrous iron and alpha-ketoglutarate-dependent dioxygenase FncG.
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