4.8 Article

Diastereoselective Synthesis of Tetracyclic Tetrahydroquinoline Derivative Enabled by Multicomponent Reaction of Isocyanide, Allenoate, and 2-Aminochalcone

Journal

ORGANIC LETTERS
Volume 23, Issue 11, Pages 4094-4098

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00912

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Funding

  1. National Key Research and Development Program of China [2017YFB0102900]
  2. Natural Science Foundation of Shanghai [18ZR1413900]
  3. School of Chemistry and Chemical Engineering, Henan Normal University
  4. Talent Project of Fuyang Normal University [2018kyqd0035]

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The multicomponent protocol reported in this study allows for the assembly of several polycyclic dihydropyran-fused tetrahydroquinoline structures with excellent diastereoselectivity, using simple feedstocks to achieve a series of diverse structures that are difficult to attain by traditional sequences.
We report here a multicomponent protocol to assemble several polycyclic dihydropyran-fused tetrahydroquinoline structures with excellent diastereoselectivity. This procedure employs simple feedstocks to accomplish a series of diverse structures, which is difficult to attain by traditional sequences.

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