Nickel-Catalyzed Reductive Vinylation of Chloro-hexahydropyrroloindoline Derivatives with Vinyl Triflates

This work emphasizes facile construction of C-3a vinyl substituted hexahydropyrrolidinoindolines based upon Ni-catalyzed reductive coupling of chloro-hexahydropyrroloindoline derivatives with a wide range of alkyl-decorated vinyl triflates. The remarkable compatibility of sterically hindered branched vinyl groups is highlighted.

Automated summary

This study demonstrates a facile method for constructing C-3a vinyl substituted hexahydropyrrolidinoindolines based on Ni-catalyzed reductive coupling, showcasing remarkable compatibility with a wide range of alkyl-decorated vinyl triflates, including sterically hindered branched vinyl groups.