Journal
ORGANIC LETTERS
Volume 23, Issue 7, Pages 2411-2414Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00036
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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A novel catalytic asymmetric reaction was reported, where the regiodivergent desymmetrisation of meso-azabicycloheptene was achieved via allylic oxidation using a single chiral copper catalyst, producing two different, enantioenriched structural isomers with high optical purity from a single compound. The enantioselectivity of the two structurally isomeric compounds was enriched to >99.5% ee after derivatization.
A novel catalytic asymmetric reaction is reported where the regiodivergent desymmetrisation of meso-azabicycloheptene via allylic oxidation using a single chiral copper catalyst produced two different, enantioenriched structural isomers in high optical purity starting from a single compound. The enantiose-lectivity of the two structurally isomeric compounds was enriched to >99.5% ee after derivatization.
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