Journal
BRAIN STIMULATION
Volume 8, Issue 6, Pages 1101-1107Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2015.06.014
Keywords
Chronic tinnitus; Therapeutic study; Transcranial direct current stimulation (tDCS); Non-invasive brain stimulation; Plasticity
Categories
Funding
- Neurology Division of the Department of Clinical Neurosciences
- Clinic of Otolaryngology, Head Neck & Ear Surgery, Centre Hospitalier Universitaire Vaudois
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Background: Tinnitus is an often disabling condition for which there is no effective therapy. Current research suggests that tinnitus may develop due to maladaptive plastic changes and altered activity in the auditory and prefrontal cortex. Transcranial direct current stimulation (tDCS) modulates brain activity and has been shown to transiently suppress tinnitus in trials. Objective: To investigate the efficacy and safety of tDCS in the treatment of chronic subjective tinnitus. Methods: In a randomized, parallel, double-blind, sham-controlled study, the efficacy and safety of cathodal tDCS to the auditory cortex with anode over the prefrontal cortex was investigated in five sessions over five consecutive days. Tinnitus was assessed after the last session on day 5, and at follow-up visits 1 and 3 months post stimulation using the Tinnitus Handicap Inventory (THI, primary outcome measure), Subjective Tinnitus Severity Scale, Hospital Anxiety and Depression scale, Visual Analogue Scale, and Clinical Global Impression scale. Results: 42 patients were investigated, 21 received tDCS and 21 sham stimulation. There were no beneficial effects of tDCS on tinnitus as assessed by primary and secondary outcome measures. Effect size assessed with Cohen's d amounted to 0.08 (95% CI: -0.52 to 0.69) at 1 month and 0.18 (95% CI: -0.43 to 0.78) at 3 months for the THI. Conclusion: tDCS of the auditory and prefrontal cortices is safe, but does not improve tinnitus. Different tDCS protocols might be beneficial. (C) 2015 Elsevier Inc. All rights reserved.
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