Journal
NUTRITION REVIEWS
Volume 80, Issue 1, Pages 68-77Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/nutrit/nuab011
Keywords
berry; clinical trial design; dietary intervention; evidence mapping; health criteria
Categories
Funding
- Wild Blueberry Association of North America
- United States Department of Agriculture National Institute of Food and Agriculture [02689]
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Consumption of berries is associated with various health benefits, but there are still questions about the mechanism of action, dosage effectiveness, and optimal intake duration and frequency. A systematic assessment of current research is needed to inform future study designs and fill knowledge gaps. The development of tools to organize this information can also aid in consumer messaging, targeted nutritional health initiatives, and dietary guidelines.
Berry consumption is linked to diverse health benefits, but numerous questions remain regarding mechanism of action, dose efficacy, and optimal duration and frequency of intake. Addressing these outstanding questions requires an organized assessment of current research, to inform future study designs and fill critical knowledge gaps. Took that organize such information will also facilitate consumer messaging, targeted nutritional health initiatives, and dietary intake guidelines. This review aimed to describe the development and utility of the Berry Health Tool Chest, an evidence map summarizing trial design features of studies characterizing the impact of berry consumption upon human health biomarkers. A systematic search strategy identified relevant high-quality human feeding studies, whose study design parameters were collected and compiled into an evidence map that is freely available as an interactive online interface enabling tabulated data to be interrogated, filtered, and exported. Of the 231 included studies, approximately 70% were of less than 3 months' duration and/or fewer than 50 participants, illustrating research gaps that could potentially inform the design of future studies.
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