Concurrent zinc and vitamin B6 deficiencies in acutely exacerbated inflammatory bowel disease: Case reports

Background Limited evidence is available to describe the prevalence, causes, and consequences of zinc and vitamin B-6 deficiencies in those with acutely exacerbated inflammatory bowel disease (IBD). Zinc is important for immune function and wound healing, and B-6 is needed for metabolic and neurological function. Patients with IBD are at risk of micronutrient deficiencies, particularly during flares. Presentations The cases of 2 patients with IBD exacerbations were reviewed in which deficiencies of both zinc and vitamin B-6 were identified. Conclusions These cases highlight the need for increased screening for zinc and pyridoxine deficiencies in IBD population, especially during disease exacerbation. Therefore, we recommend a comprehensive nutrition workup with physical exam, diet history, and a complete micronutrient panel while ruling out contributing factors. If patients are susceptible to deficiencies during flares, prophylactic oral zinc and pyridoxine supplementation may be considered, with close monitoring for subsequent iron and copper deficiencies.

Automated summary

Limited evidence is available on the prevalence, causes, and consequences of zinc and vitamin B-6 deficiencies in those with acutely exacerbated inflammatory bowel disease. Cases of two patients with IBD exacerbations demonstrated the need for increased screening for these deficiencies during disease exacerbation. Prophylactic oral zinc and pyridoxine supplementation may be considered for patients at risk for deficiencies during flares, with close monitoring for subsequent iron and copper deficiencies.