Journal
BRAIN STIMULATION
Volume 8, Issue 5, Pages 993-1006Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.brs.2015.06.017
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Funding
- Swedish Research Council [2011-38769-82837-71]
- MRC [MR/K01384X/1] Funding Source: UKRI
- Medical Research Council [MR/K01384X/1] Funding Source: researchfish
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Homeostatic plasticity is thought to stabilize neural activity around a set point within a physiologically reasonable dynamic range. Over the last ten years, a wide range of non-invasive transcranial brain stimulation (NTBS) techniques have been used to probe homeostatic control of cortical plasticity in the intact human brain. Here, we review different NTBS approaches to study homeostatic plasticity on a systems level and relate the findings to both, physiological evidence from in vitro studies and to a theoretical framework of homeostatic function. We highlight differences between homeostatic and other non-homeostatic forms of plasticity and we examine the contribution of sleep in restoring synaptic homeostasis. Finally, we discuss the growing number of studies showing that abnormal homeostatic plasticity may be associated to a range of neuropsychiatric diseases. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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