4.8 Article

Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD

Related references

Note: Only part of the references are listed.
Article Transplantation

Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, for treatment of anemia of chronic kidney disease: two randomized Phase 2 trials in Japanese patients

Masaomi Nangaku et al.

Summary: The results of the studies support the development of vadadustat for the treatment of anemia in patients with CKD, showing significant efficacy in increasing Hb levels and adjusting iron utilization and mobilization. The incidence of adverse events during the primary efficacy period was similar to or slightly higher than the placebo group, with common events including nausea, hypertension, diarrhea, and nasopharyngitis.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

Article Cardiac & Cardiovascular Systems

Cardiovascular safety and efficacy of vadadustat for the treatment of anemia in non-dialysis-dependent CKD: Design and baseline characteristics

Glenn M. Chertow et al.

Summary: Vadadustat, an investigational oral hypoxia-inducible factor prolyl-hydroxylase inhibitor, is being studied for its safety and efficacy in managing anemia in non-dialysis-dependent chronic kidney disease patients. The trials will evaluate the change in hemoglobin levels between vadadustat and darbepoetin alfa treatments in different anemia patients, with similar demographics and baseline characteristics among participants.

AMERICAN HEART JOURNAL (2021)

Article Medicine, General & Internal

Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis

Kai-Uwe Eckardt et al.

Summary: Vadadustat, an oral prolyl hydroxylase inhibitor, was found to be noninferior to darbepoetin alfa in terms of cardiovascular safety and hemoglobin concentration in anemia patients with CKD undergoing dialysis, based on two phase 3 trials.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Urology & Nephrology

Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease

Edouard R. Martin et al.

AMERICAN JOURNAL OF NEPHROLOGY (2017)

Article Multidisciplinary Sciences

Prevalence of Anemia in Chronic Kidney Disease in the United States

Melissa E. Stauffer et al.

PLOS ONE (2014)

Review Hematology

Regulation of erythropoiesis by hypoxia-inducible factors

Volker H. Haase

BLOOD REVIEWS (2013)

Article Medicine, General & Internal

Peginesatide for Anemia in Patients with Chronic Kidney Disease Not Receiving Dialysis

Iain C. Macdougall et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Peginesatide in Patients with Anemia Undergoing Hemodialysis

Steven Fishbane et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factors in Physiology and Medicine

Gregg L. Semenza

Article Urology & Nephrology

Notice

Kidney International Supplements (2012)

Article Urology & Nephrology

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

Wanja M. Bernhardt et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Article Medicine, General & Internal

A New Equation to Estimate Glomerular Filtration Rate

Andrew S. Levey et al.

ANNALS OF INTERNAL MEDICINE (2009)

Article Medicine, General & Internal

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

Marc A. Pfeffer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Biochemistry & Molecular Biology

Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway

William G. Kaelin et al.

MOLECULAR CELL (2008)

Article Medicine, General & Internal

Correction of anemia with epoetin alfa in chronic kidney disease

Ajay K. Singh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Medicine, General & Internal

Normalization of hemoglobin level in patients with chronic kidney disease and anemia

Tilman B. Drueke et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)