Fast-Trk(B)ing the mechanism of antidepressants

The mechanism by which antidepressants elicit clinical improvements has proven elusive. In a recent publication in Cell, Casarotto et al. (2021) reveal a surprising direct interaction between antidepressants and TrkB. This link provides an important mechanistic insight into synaptic remodeling that may assist in the design of improved antidepressant therapeutics.

Automated summary

The direct interaction between antidepressants and TrkB revealed in a recent study sheds light on synaptic remodeling mechanisms, potentially enhancing the development of improved antidepressant therapeutics.