On location for cannabinoid control of multimodal behavior

In this issue of Neuron, Soria-Gomez et al. (2021) investigate whether activation of the type 1 cannabinoid receptor at specific subcellular locations within a single neural circuit produces multimodal behavior. Their results demonstrate that location matters: striatonigral mitochondrial CB1 drives catalepsy while striatonigral plasma membrane CB1 receptors enable antinociception.

Automated summary

The study investigates the effects of activation of the type 1 cannabinoid receptor at specific subcellular locations within a single neural circuit, showing that the location of the receptor determines the behavioral outcome, with striatonigral mitochondrial CB1 driving catalepsy and striatonigral plasma membrane CB1 receptors enabling antinociception.