Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 145, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2021.104991
Keywords
Air pollution; Remyelination; Multiple sclerosis; Oligodendrocytes; Glial reactivity
Categories
Funding
- FISM - Fondazione Italiana Sclerosi Multipla (Italy) [2019/PR-Multi/003]
- Ministero dell'Istruzione, dell'Universita e della Ricerca-MIUR (Italy)
- '5 per mille' public funding
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Studies suggest that exposure to fine PM may disrupt the CNS tissue's endogenous regenerative capability, potentially contributing to demyelinating pathologies such as Multiple Sclerosis.
Epidemiological studies show a strong association between exposure to air pollution ? and particularly to particulate matter (PM)-, increased prevalence of Multiple Sclerosis (MS) and higher rates of hospital admissions for MS and MS relapses. Besides having immunomodulatory effects and sustaining a systemic oxidative inflammatory response, PM may participate in MS pathogenesis by targeting also Central Nervous System (CNS)-specific processes, such as myelin repair. Here we show that, in a mouse model of lysolecithin-induced demyelination of the subcortical white matter, post-injury exposure to fine PM hampers remyelination, disturbs oligodendroglia differentiation dynamics and promotes astroglia and microglia reactivity. These findings support the view that exposure to fine PM can contribute to demyelinating pathologies by targeting the endogenous regenerative capability of the CNS tissue.
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