Journal
NEUROCASE
Volume 27, Issue 2, Pages 223-226Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13554794.2021.1921222
Keywords
Neuromyelitis optica spectrum disorders; anti-aquaporin 4 antibody; parkinsonism; dementia; basal ganglia
Categories
Funding
- Japanese Ministry of Education, Culture, Sports, Science, and Technology
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This case demonstrates that NMOSD associated with dementia and/or Parkinson-like syndrome with basal ganglia lesions could be another clinical presentation in NMOSD, even in sites not enriched with AQP4.
Brain lesions in neuromyelitis optica spectrum disorders (NMOSD) are generally located at sites of high anti-aquaporin 4 (AQP4) expression. Clinical features of NMOSD associated with basal ganglia damage in sites not enriched with AQP4 remain unknown. Here we describe the case of an 82-year-old woman who developed dementia and bradykinesia for 5 weeks. Brain magnetic resonance imaging revealed obvious basal ganglia abnormalities. Test for serum anti-AQP4 antibody was positive, and she was diagnosed with NMOSD. Our case showed that NMOSD associated with dementia and/or Parkinson-like syndrome with basal ganglia lesions could be another clinical presentation in NMOSD.
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