Journal
NATURE MEDICINE
Volume 27, Issue 4, Pages 601-615Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-021-01283-z
Keywords
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Funding
- National Institutes of Health [K23 DK111847]
- Department of Defense [PR181960]
- National Institutes of Health/National Heart, Lung, and Blood Institute [T32 HL007854]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01-DK114893, R01-MD014161, U01-DK116066]
- National Science Foundation [2032726]
- National Institute of Neurological Disorders and Stroke [T32 NS007153-36]
- National Institute on Aging [P30 AG066462-01]
- NIH [R01 HL152236, R03 HL146881]
- Esther Aboodi Endowed Professorship at Columbia University
- Foundation for Gender-Specific Medicine
- Wu Family Research Fund
- Louis V. Gerstner, Jr. Scholars Program
- Division Of Environmental Biology
- Direct For Biological Sciences [2032726] Funding Source: National Science Foundation
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SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics. A comprehensive review of the current literature on post-acute COVID-19, also referred to as long COVID, its pathophysiology and its organ-specific sequelae highlights the need for multidisciplinary follow-up and care of COVID-19 survivors.
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