Journal
NATURE BIOTECHNOLOGY
Volume 39, Issue 9, Pages 1078-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41587-021-00897-5
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Funding
- NIH [UH3NS100544]
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The use of an implantable two-way neural interface enables wireless neural monitoring and stimulation for up to 15 months following implantation. This technological approach may have wide applicability to brain disorders treatable by invasive neuromodulation.
Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson's disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation. An implanted device in the brain enables wireless neural monitoring and stimulation for up to 15 months following implantation.
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