4.8 Editorial Material

Previously unknown type of protein crosslink discovered

Journal

NATURE
Volume 593, Issue 7859, Pages 343-344

Publisher

NATURE PORTFOLIO
DOI: 10.1038/d41586-021-01135-3

Keywords

Biochemistry; Structural biology

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Molecular crosslinks like disulfides stabilize protein structures and regulate function, but a new type of regulatory protein crosslink involving a covalent linkage between cysteine and lysine residues has been discovered.
Molecular crosslinks known as disulfides stabilize the 3D structures of many proteins, and sometimes regulate protein function. But disulfides are not alone - another type of regulatory protein crosslink has been discovered. A covalent linkage between cysteine and lysine residues in a protein.

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