Fast odour dynamics are encoded in the olfactory system and guide behaviour

Odours are transported in turbulent plumes, which result in rapid concentration fluctuations(1,2) that contain rich information about the olfactory scenery, such as the composition and location of an odour source(2-4). However, it is unclear whether the mammalian olfactory system can use the underlying temporal structure to extract information about the environment. Here we show that ten-millisecond odour pulse patterns produce distinct responses in olfactory receptor neurons. In operant conditioning experiments, mice discriminated temporal correlations of rapidly fluctuating odours at frequencies of up to 40 Hz. In imaging and electrophysiological recordings, such correlation information could be readily extracted from the activity of mitral and tufted cells-the output neurons of the olfactory bulb. Furthermore, temporal correlation of odour concentrations5 reliably predicted whether odorants emerged from the same or different sources in naturalistic environments with complex airflow. Experiments in which mice were trained on such tasks and probed using synthetic correlated stimuli at different frequencies suggest that mice can use the temporal structure of odours to extract information about space. Thus, the mammalian olfactory system has access to unexpectedly fast temporal features in odour stimuli. This endows animals with the capacity to overcome key behavioural challenges such as odour source separation(5), figure-ground segregation6 and odour localization(7) by extracting information about space from temporal odour dynamics.

Automated summary

Researchers have found that the mammalian olfactory system can extract information about the environment using the temporal structure in odours. Mice in experiments were able to discriminate temporal correlations of rapidly fluctuating odours, and this information could be extracted from the activity of mitral and tufted cells.