Universal nomenclature for oxytocin-vasotocin ligand and receptor families

Oxytocin (OXT; hereafter OT) and arginine vasopressin or vasotocin (AVP or VT; hereafter VT) are neurotransmitter ligands that function through specific receptors to control diverse functions(1,2). Here we performed genomic analyses on 35 species that span all major vertebrate lineages, including newly generated high-contiguity assemblies from the Vertebrate Genomes Project(3,4). Our findings support the claim(5) that OT (also known as OXT) and VT (also known as AVP) are adjacent paralogous genes that have resulted from a local duplication, which we infer was through DNA transposable elements near the origin of vertebrates and in which VT retained more of the parental sequence. We identified six major oxytocin-vasotocin receptors among vertebrates. We propose that all six of these receptors arose from a single receptor that was shared with the common ancestor of invertebrates, through a combination of whole-genome and large segmental duplications. We propose a universal nomenclature based on evolutionary relationships for the genes that encode these receptors, in which the genes are given the same orthologous names across vertebrates and paralogous names relative to each other. This nomenclature avoids confusion due to differential naming in the pre-genomic era and incomplete genome assemblies, furthers our understanding of the evolution of these genes, aids in the translation of findings across species and serves as a model for other gene families. A revised, universal nomenclature for the vertebrate genes that encode the oxytocin and vasopressin-vasotocin ligands and receptors will improve our understanding of gene evolution and facilitate the translation of findings across species.

Automated summary

The study indicates that oxytocin and vasopressin are adjacent paralogous genes that likely resulted from a local duplication through DNA transposable elements near the origin of vertebrates, with vasotocin retaining more of the parental sequence. Six major oxytocin-vasotocin receptors were identified among vertebrates, potentially originating from a single receptor shared with the common ancestor of invertebrates through whole-genome and large segmental duplications.