First complete model of the human embryo

Review Chemistry, Physical

Stem-cell-based embryo models for fundamental research and translation

Jianping Fu et al.

Summary: This article highlights the importance of stem-cell-derived embryo models in advancing our understanding of mammalian embryology, emphasizing the significance of simulating mouse and human development in current models and utilizing bioengineering tools.

NATURE MATERIALS (2021)

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Article Multidisciplinary Sciences

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

Xiaodong Liu et al.

Summary: The study describes a method to reprogram fibroblasts into human blastocyst models, known as iBlastoids. This model can mimic the overall structure of blastocysts, including inner cell mass, epiblast, primitive endoderm-like cells, blastocoel-like cavity, and trophectoderm-like cells. The iBlastoids system is believed to facilitate the study of early human development, the effects of gene mutations and toxins during early embryogenesis, and the development of new therapies associated with in vitro fertilization.

NATURE (2021)

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Article Multidisciplinary Sciences

Blastocyst-like structures generated from human pluripotent stem cells

Leqian Yu et al.

Summary: The study developed an effective three-dimensional culture strategy to generate blastocyst-like structures in vitro which resemble human blastocysts. These structures, termed 'human blastoids', are readily accessible, scalable, versatile, and perturbable alternative to blastocysts for studying early human development, understanding early pregnancy loss, and gaining insights into early developmental defects.

NATURE (2021)

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Article Multidisciplinary Sciences