Journal
NATURAL PRODUCT COMMUNICATIONS
Volume 16, Issue 4, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X211008322
Keywords
tetralone derivative; marine-derived fungus; Cladosporium sp.; bioactivity; deep sea
Categories
Funding
- National Science and Technology Major Project for Significant New Drugs Development [2018ZX09735004]
- Major Basic Research Programs of Natural Science Foundation of Shandong Province [ZR2019ZD18]
- Fundamental Research Funds for the Central Universities [201941001]
- Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) [2018SDKJ0401-2]
- Youth Innovation Plan of Shandong Province [2019KJM004]
- Taishan Scholar Youth Expert Program in Shandong Province [tsqn201812021]
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A new tetralone derivative, aladothalen, and a known biogenetically related compound were isolated from a deep-sea-derived-fungal Cladosporium sp. HDN17-58. Compound 1 showed strong bacteriostatic activity against various bacteria with a MIC value of 25 mu M.
One new tetralone derivative, named aladothalen (1), and one known biogenetically related compound, (3S,4S)-3,4,8-trihydroxy-3,4-dihydronaphthalen-1(2 hours)-one (2), were isolated from a deep-sea-derived-fungal Cladosporium sp. HDN17-58. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compound 1 exhibited potent bacteriostatic activity against Bacillus cereus, Mycobacterium phlei and methicillin-resistant coagulase-negative Staphylococci, with a MIC value of 25 mu M.
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