Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 37, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.nano.2021.102408
Keywords
Graphene quantum dots; Imaging; Cancer therapy; Targeting; Redox-based drug delivery
Funding
- Texas Christian University [70584]
- TCU Invests in Scholarship [60916]
- RCAF Grant [60852]
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This study developed a new multifunctional biocompatible anticancer nanoformulation that provides targeted image-guided cancer therapy, demonstrating capabilities in treatment, imaging, and specific targeting of cancer cells.
This work develops a new multifunctional biocompatible anticancer nanoformulation to provide targeted image-guided cancer-selective therapeutics. It consists of three active covalently bound components: (1) biocompatible nitrogen-doped graphene quantum dots (GQDs) as a multifunctional delivery and imaging platform, (2) hyaluronic acid (HA) unit targeted to the CD44 receptors on a variety of cancer cells, and (3) oxidative stress-based cancer-selective ferrocene (Fc) therapeutic. The biocompatible GQD platform synthesized from glucosamine exhibits high-yield intrinsic fluorescence. It is utilized for tracking Fc-GQD-HA formulation in vitro indicating internalization enhancement in HeLa cells targeted by the HA over non-cancer HEK-293 cells not overexpressing CD44 receptor. Fc-GQD-HA, non-toxic at 1 mg/mL to HEK-293 cells, induces cytotoxic response in HeLa enhanced over time, while therapeutic ROS generation by Fc-GQD-HA is similar to 3 times greater than that of Fc alone. This outlines the targeted delivery, imaging, and cancer-specific treatment capabilities of the new Fc-GQD-HA formulation enabling desired cancer-focused nanotherapeutic approach. (C) 2021 Elsevier Inc. All rights reserved.
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