Journal
NANOMEDICINE
Volume 16, Issue 12, Pages -Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0382
Keywords
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Funding
- Nanobiotechnology Task Force (Department of Biotechnology, Government of India) [BT/PK 7665/NNT/28/658/2013]
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The study team developed a method to convert total blood serum into chemo drug-loaded nanoparticles and demonstrated its significant antitumor efficacy in vitro and in vivo.
Aim: To develop a method for making total serum nanoparticles (TSN) loaded with cytotoxic chemodrugs for cancer therapy. Materials & methods: TSN loaded with paclitaxel (PTX) or piperlongumine (PL) were prepared using high-pressure homogenization and tested for immunogenicity in healthy animals and antitumor properties in pancreatic cancer xenograft models. Results: TSN-PL nanoparticles of average size 104 nm and encapsulation efficiency approximately 50% showed enhanced dose-dependent cytotoxicity compared with TSN-PTX or clinically used combination of gemcitabine and nano-PTX in two pancreatic cell lines. Significant antitumor efficacy was also established in the pancreatic xenograft model. Conclusion: We developed a unique method of converting total blood serum into chemo drug-loaded nanoparticles and demonstrated its efficacy in vitro and in vivo.
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