Journal
NANOMEDICINE
Volume 16, Issue 11, Pages 943-962Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0442
Keywords
iron oxide nanoparticles (IONPs); magnetic hyperthermia therapy (MHT); MRI; near infra-red (NIR); optical imaging (OI); photodynamic therapy (PDT); photosensitizers (PS); photothermal therapy (PTT)
Funding
- UKIERI-UGC Joint Research Program (UKIERI III) research grant [IND/CONT/G/16-17/62]
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Functional inorganic nanoparticles play a significant role in biomedical research, with IONPs being particularly useful for targeting, imaging, and therapy; combining organic optical probes with IONPs can enhance their biomedical applications; the multimodality of nanoparticles can provide synergistic benefits in disease detection and therapy.
The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key trait of nanoparticles for advanced biomedical applications. This review focuses on the use of IONPs conjugated with organic optical probe/s for multimodal diagnostic and therapeutic applications in vivo.
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