4.8 Article

A highly accessible copper single-atom catalyst for wound antibacterial application

Journal

NANO RESEARCH
Volume 14, Issue 12, Pages 4808-4813

Publisher

TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-021-3432-x

Keywords

copper single-atom catalyst; mesoporous carbon nanospheres; catalytic transformation of oxygen; oxidative stress; bacterial infection healing

Funding

  1. National Key R&D Program of China 2017YFA [0208300, 0700104]
  2. National Natural Science Foundation of China [21671180]
  3. CAS Fujian Institute of Innovation
  4. Cooperation Fund [DNL201918]

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A highly accessible copper single-atom catalyst was synthesized in this study, showing efficient elimination of various bacterial infections and promotion of wound healing.
Bacterial infection arised from multipathogenic bacteria is a tricky issue that attracts worldwide attentions. In this paper, a highly accessible copper single-atom catalyst (Cu SAC) supported by biocompatible N-doped mesoporous carbon nanospheres was synthesized with the emulsion-template method. The tightly anchored copper single-atom of the catalyst could effectively transform O-2 into O-2(-center dot) under ambient conditions by the ultra-large pore size (similar to 23.80 nm) and small particle size (similar to 97.71 nm). Due to multiple synergistically oxidative damages to biomolecules, the Cu SAC could be employed to eliminate different bacteria in vitro without the generation of multidrug resistance (MDR). Moreover, the Cu SAC could also promote wound healing in vivo by eradicating the propagation of bacteria at wound. It is envisioned that the Cu SAC with superior antibacterial performance could be applied in the treatment of related bacterial infection in future.y

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