Journal
NANO LETTERS
Volume 21, Issue 6, Pages 2562-2571Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c05148
Keywords
Atomic Engineering; Clusterzyme; Acute Inflammation
Categories
Funding
- NSFC [91859101, 81971744, U1932107, 82001952, 81471786]
- National Natural Science Foundation of Tianjin [19JCZDJC34000]
- Foundation of 'Peiyang Young Researcher' Program of Tianjin University
- CAS Interdisciplinary Innovation Team [JCTD-2020-08]
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The artificially engineered Au24Ag1 clusterzyme exhibits high catalytic activity and stability through atomic manipulation, showing an antioxidant property 72 times higher than that of natural antioxidant Trolox. Furthermore, it demonstrates distinctive reactions against inflammation by inhibiting cytokines in the brain at an early stage.
Natural enzymes are efficient and versatile biocatalysts but suffer in their environmental tolerance and catalytic stability. As artificial enzymes, nanozymes can improve the catalytic stability, but it is still a challenge to achieve high catalytic activity. Here, we employed atomic engineering to build the artificial enzyme named Au24Ag1 clusterzyme that hosts an ultrahigh catalytic activity as well as strong physiological stability via atom manipulation. The designed Au24Ag1 clusterzyme activates the Ag-S active site via lattice expansion in the oligomer atom layer, showing an antioxidant property 72 times higher than that of natural antioxidant Trolox. Enzyme-mimicked studies find that Au24Ag1 clusterzyme exhibits high catalase-like (CAT-like) and glutathione peroxidase-like (GPx-like) activity with a maximum reaction rate of 68.9 and 17.8 mu M/min, respectively. Meanwhile, the unique catalytic landscape exhibits distinctive reactions against inflammation by inhibiting the cytokines at an early stage in the brain. Atomic engineering of clusterzymes provides a powerful and attractive platform with satisfactory atomic dispersion for tailoring biocatalysts freely at the atomic level.
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