Journal
MOLECULES
Volume 26, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules26103040
Keywords
alkaloids; vincamine; antioxidant; antibacterial; phenolic compounds
Funding
- project Entrepreneurship for innovation through doctoral and postdoctoral research [POCU/360/6/13/123886]
- European Social Fund, through the Operational Program for Human Capital 2014-2020
- 2020 Development Fund of the 'Babes,-Bolyai' University
- Ministry of Research, Innovation and Digitization, CNCS/CCCDI-UEFISCDI, within PNCDI III [TE-2019-1396]
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The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts revealed species-specific antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. V. herbacea showed the highest antioxidant activity and antibacterial potential, while V. minor exhibited the most significant inhibitory effect against Staphylococcus aureus and E. coli.
The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts showed species-dependent antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. Vincamine was present in V. minor, V. major, and V. major var. variegata, while V. minor had the richest alkaloid content, followed by V. herbacea. V. major var. variegata was richest in flavonoids and the highest total phenolic content was found in V. herbacea which also had elevated levels of rutin. Consequently, V. herbacea had the highest antioxidant activity followed by V. major var. variegata. Whereas, the lowest one was of V. major. The V. minor extract showed the most efficient inhibitory effect against both Staphylococcus aureus and E. coli. On the other hand, V. herbacea had a good anti-bacterial potential only against S. aureus, which was most affected at morphological levels, as indicated by scanning electron microscopy. The Vinca extracts acted in a dose-depended manner against HaCaT keratinocytes and A375 melanoma cells and moreover, with effects on the ultrastructure, nitric oxide concentration, and lactate dehydrogenase release. Therefore, the Vinca species could be exploited further for the development of alternative treatments in bacterial infections or as anticancer adjuvants.
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