4.6 Review

The Anti-Leukemic Activity of Natural Compounds

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Caffeic Acid Enhances the Anti-Leukemic Effect of Imatinib on Chronic Myeloid Leukemia Cells and Triggers Apoptosis in Cells Sensitive and Resistant to Imatinib

Giordana Feriotto et al.

Summary: Caffeic acid demonstrated anti-proliferative and apoptosis-inducing effects on chronic myeloid leukemia cells at micro-molar concentrations, by increasing the expression of cell cycle repressor genes. Additionally, it enhanced the anti-leukemic effect of imatinib, highlighting its nutraceutical potential in CML.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Cytotoxic effect of 6-Shogaol in Imatinib sensitive and resistant K562 cells

Tulin Ozkan et al.

Summary: The study demonstrates that 6-Shogaol inhibits cell viability and induces apoptosis in CML cell lines, affecting the expression levels of apoptotic-related genes. It also shows potential anticancer effects of 6-SG in treating IMA resistance in CML therapy.

MOLECULAR BIOLOGY REPORTS (2021)

Review Chemistry, Medicinal

Parthenolide as Cooperating Agent for Anti-Cancer Treatment of Various Malignancies

Malgorzata Sztiller-Sikorska et al.

PHARMACEUTICALS (2020)

Review Biotechnology & Applied Microbiology

Mechanisms of drug resistance in acute myeloid leukemia

Jing Zhang et al.

ONCOTARGETS AND THERAPY (2019)

Article Medicine, General & Internal

Side effects from acute myeloid leukemia treatment: results from a national survey

Norah L. Crossnohere et al.

CURRENT MEDICAL RESEARCH AND OPINION (2019)

Article Cell Biology

Quercetin sensitizes human myeloid leukemia KG-1 cells against TRAIL-induced apoptosis

Adel Naimi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Cell Biology

Curcumin as a therapeutic agent in leukemia

Hamideh Kouhpeikar et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Chemistry, Medicinal

Pterostilbene increases Fas expression in T-lymphoblastic leukemia cell lines

Gelareh Ramezani et al.

RESEARCH IN PHARMACEUTICAL SCIENCES (2019)

Article Oncology

Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells

Ergul Mutlu Altundag et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2018)

Article Medicine, Research & Experimental

Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition

Ruixin Gu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biochemistry & Molecular Biology

Metabolic responses and arginine kinase expression of juvenile cuttlefish (Sepia pharaonis) under salinity stress

Shang-Jun Yin et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Review Plant Sciences

Anti-inflammatory effects of luteolin: A review of in vitro, in vivo, and in silico studies

Nur Aziz et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

Article Microbiology

Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications

Mehdi Sharifi-Rad et al.

MICROBIOLOGICAL RESEARCH (2018)

Letter Pharmacology & Pharmacy

Chemical properties of thymoquinone, a monoterpene isolated from the seeds of Nigella sativa Linn.

Randolph R. J. Arroo et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Food Science & Technology

Anthocyanin-rich bilberry extract induces apoptosis in acute lymphoblastic leukemia cells via redox-sensitive epigenetic modifications

Antonio J. Leon-Gonzalez et al.

JOURNAL OF FUNCTIONAL FOODS (2018)

Article Multidisciplinary Sciences

Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells

Andrana Karla Calgarotto et al.

SCIENTIFIC REPORTS (2018)

Article Cell Biology

Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species

Gabriela Flores-Lopez et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Review Hematology

Advances in targeted therapy for acute myeloid leukaemia

Sabine Kayser et al.

BRITISH JOURNAL OF HAEMATOLOGY (2018)

Article Oncology

B-Cell Disorders and Curcumin

Terry Golombick et al.

INTEGRATIVE CANCER THERAPIES (2017)

Article Hematology

Antiproliferative and Apoptosis-Inducing Activities of Thymoquinone in Lymphoblastic Leukemia Cell Line

Amin Soltani et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2017)

Article Hematology

Antiproliferative and Apoptosis-Inducing Activities of Thymoquinone in Lymphoblastic Leukemia Cell Line

Amin Soltani et al.

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION (2017)

Review Chemistry, Medicinal

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer

Prashant Joshi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Chemistry, Applied

Phytochemical analysis of Achillea ligustica All. from Lipari Island (Aeolian Islands)

Alessandro Venditti et al.

NATURAL PRODUCT RESEARCH (2016)

Article Chemistry, Multidisciplinary

Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy

Hong Liu et al.

ACTA PHARMACOLOGICA SINICA (2016)

Review Cell Biology

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Lucio G. Costa et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Chemistry, Medicinal

Curcumin enhances the cytogenotoxic effect of etoposide in leukemia cells through induction of reactive oxygen species

Monika Papiez et al.

Drug Design Development and Therapy (2016)

Article Oncology

Chrysin Induces Apoptosis in Peripheral Blood Lymphocytes Isolated from Human Chronic Lymphocytic Leukemia

Milan Zaric et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells

Dan-yue Peng et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2015)

Review Medicine, General & Internal

Acute Myeloid Leukemia

Hartmut Doehner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Plant Sciences

Antioxidant and alpha-glucosidase inhibitory activities of Achillea tenorii

Alessandro Venditti et al.

PHARMACEUTICAL BIOLOGY (2015)

Article Medicine, Research & Experimental

Effect of quercetin on the proliferation of the human ovarian cancer cell line SKOV-3 in vitro

Ming-Xin Ren et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

Article Medicine, Research & Experimental

Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro

Jian Ouyang

MEDICAL SCIENCE MONITOR (2015)

Article Biochemistry & Molecular Biology

Discovery of Potent Parthenolide-Based Antileukemic Agents Enabled by Late-Stage P450-Mediated C-H Functionalization

Joshua N. Kolev et al.

ACS CHEMICAL BIOLOGY (2014)

Article Oncology

Multitarget Effects of Quercetin in Leukemia

Victor Maso et al.

CANCER PREVENTION RESEARCH (2014)

Article Integrative & Complementary Medicine

Effects of quercetin on hedgehog signaling in chronic myeloid leukemia KBM7 cells

Li Wei et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2014)

Article Oncology

Emodin enhances ATRA-induced differentiation and induces apoptosis in acute myeloid leukemia cells

Yingyu Chen et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Review Cell Biology

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Peter E. Czabotar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Hematology

Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment

Michael Hallek

AMERICAN JOURNAL OF HEMATOLOGY (2013)

Article Chemistry, Medicinal

Flavonoids as receptor tyrosine kinase FLT3 inhibitors

Young-Won Chin et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Review Pharmacology & Pharmacy

Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea

J. Steinmann et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Article Integrative & Complementary Medicine

Resveratrol Downregulates Interleukin-6-Stimulated Sonic Hedgehog Signaling in Human Acute Myeloid Leukemia

Yu-Chieh Su et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Review Oncology

Bcl-2 antagonists: a proof of concept for CLL therapy

Kumudha Balakrishnan et al.

INVESTIGATIONAL NEW DRUGS (2013)

Article Biochemistry & Molecular Biology

Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro

Landa Zeenelabdin Ali Salim et al.

MOLECULES (2013)

Review Medicine, Research & Experimental

The molecular basis of T cell acute lymphoblastic leukemia

Pieter Van Vlierberghe et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Biochemistry & Molecular Biology

A Historical Overview of Natural Products in Drug Discovery

Daniel A. Dias et al.

METABOLITES (2012)

Article Pharmacology & Pharmacy

Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo

Wang Chun-Guang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

Article Hematology

Epidemiology of chronic myeloid leukaemia (CML)

Maren Rohrbacher et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2009)

Review Biochemistry & Molecular Biology

Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells

Beata Pajak et al.

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2008)

Article Plant Sciences

Antileukemic activity of genistein, a major isoflavone present in soy products

Noeel J. -M. Raynal et al.

JOURNAL OF NATURAL PRODUCTS (2008)

Article Pharmacology & Pharmacy

Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats

Tian Tang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress

Rentian Feng et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Medicine, General & Internal

Chronic myeloid leukemia: Pathophysiology, diagnostic parameters, and current treatment concepts

C Sillaber et al.

WIENER KLINISCHE WOCHENSCHRIFT (2003)

Review Pharmacology & Pharmacy

Cancer chemoprevention drug targets

K Krishnan et al.

CURRENT DRUG TARGETS (2003)

Article Hematology

Analysis of resveratrol-induced apoptosis in human B-cell chronic leukaemia

V Roman et al.

BRITISH JOURNAL OF HAEMATOLOGY (2002)

Review Nutrition & Dietetics

Anticancer and health protective properties of citrus fruit components

J Silalahi

ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION (2002)