Journal
MOLECULES
Volume 26, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/molecules26071986
Keywords
multicomponent reaction; five-component; pseudo; one-pot; cascade; consecutive; green synthesis; heterocycle; pot; atom; step economy
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Multicomponent reactions (MCRs) are gaining increasing attention due to their high efficiency, resource conservation, and minimal waste. This review article discusses recent developments in 5-component reactions (5CRs), including different types and reactions with more than five reaction centers.
Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.
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