4.6 Review

Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Elevated ABCB1 Expression Confers Acquired Resistance to Aurora Kinase Inhibitor GSK-1070916 in Cancer Cells

Zhuo-Xun Wu et al.

Summary: The overexpression of ABCB1 transporter can confer resistance to GSK-1070916, and this resistance can be overcome by the addition of an ABCB1 inhibitor. GSK-1070916 stimulates the ATPase activity of ABCB1 in a concentration-dependent manner and shows high binding affinity to the ABCB1 substrate-binding site in computational docking analysis.

FRONTIERS IN PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

Saleh A. Almatroodi et al.

Summary: Polyphenolic flavonoids, especially Quercetin, exhibit potent antioxidant and anticancer properties. Quercetin can target specific molecular signaling pathways involved in cancer progression and has shown promising therapeutic potential in various types of cancers. More research is needed to fully understand the exact mechanism of action of Quercetin in cancer treatment.

MOLECULES (2021)

Article Cell Biology

Targeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance

Ming Li et al.

Summary: Research identified Tanshinone IIA as a potential Aurora B kinase inhibitor, which can inhibit malignant phenotypes of oral squamous cell carcinoma and has therapeutic potentials for cancer treatment.

CELL DEATH & DISEASE (2021)

Article Chemistry, Physical

Design, synthesis and molecular docking study of new purine derivatives as Aurora kinase inhibitors

Mohamed E. Khalifa

Summary: Nine new purine-based compounds were designed and synthesized, characterized by physical and spectroscopic methods, and tested for their anti-cancer activity against various human cancer cell lines. The compounds showed higher efficiency against breast cancer cell lines and were docked with an anticancer enzyme for understanding the mechanism of action.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Ophthalmology

Aurora Kinase B Expression, Its Regulation and Therapeutic Targeting in Human Retinoblastoma

Naheed Arfin Borah et al.

Summary: The study revealed that AURKB is overexpressed in RB tissues, and targeting it specifically may restrict tumor cell growth. MYCN is a key regulator of AURKB expression in RB.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

Article Medicine, Research & Experimental

Effect of CCT137690 on long non-coding RNA expression profiles in MCF-7 and MDA-MB-231 cell lines

Tugce Balci Okcanoglu et al.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES (2020)

Article Instruments & Instrumentation

Augmentation of danusertib's anticancer activity against melanoma by blockage of autophagy

Yuan-Yuan Shang et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

Article Chemistry, Medicinal

Discovery of SP-96, the first non-ATP-competitive Aurora Kinase B inhibitor, for reduced myelosuppression

Naga Rajiv Lakkaniga et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Oncology

Promising Therapy in Lung Cancer: Spotlight on Aurora Kinases

Domenico Galetta et al.

CANCERS (2020)

Article Medicine, Research & Experimental

HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E

Xiaoyu Chang et al.

THERANOSTICS (2020)

Review Oncology

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

Bethsebie Lalduhsaki Sailo et al.

CANCERS (2019)

Article Multidisciplinary Sciences

AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy

Jordi Bertran-Alamillo et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms

Keli Lima et al.

SCIENTIFIC REPORTS (2019)

Review Chemistry, Medicinal

Inhibition of Pyruvate Dehydrogenase Kinase as a Therapeutic Strategy against Cancer

Swatishree Sradhanjali et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)

Review Cell Biology

The functional diversity of Aurora kinases: a comprehensive review

Estelle Willems et al.

CELL DIVISION (2018)

Article Biochemistry & Molecular Biology

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

Zefang Tang et al.

NUCLEIC ACIDS RESEARCH (2017)

Review Oncology

Aurora kinases: novel therapy targets in cancers

Anqun Tang et al.

ONCOTARGET (2017)

Review Oncology

Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer

Christopher C. Mills et al.

CANCER RESEARCH (2017)

Article Pharmacology & Pharmacy

A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia

Janna K. Duong et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2017)

Article Oncology

Aurora B expression modulates paclitaxel response in non-small cell lung cancer

Ahmed S. K. Al-Khafaji et al.

BRITISH JOURNAL OF CANCER (2017)

Article Oncology

A phase I study of BI 811283, an Aurora B kinase inhibitor, in patients with advanced solid tumors

Klaus Mross et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)

Article Oncology

Quercetin suppresses lung cancer growth by targeting Aurora B kinase

Zhu Xingyu et al.

CANCER MEDICINE (2016)

Article Oncology

Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells

Stine Hole et al.

BREAST CANCER RESEARCH AND TREATMENT (2015)

Letter Hematology

A phase II trial of AZD1152 in relapsed/refractory diffuse large B-cell lymphoma

Graham P. Collins et al.

BRITISH JOURNAL OF HAEMATOLOGY (2015)

Article Biochemistry & Molecular Biology

Spatial Compartmentalization Specializes the Function of Aurora A and Aurora B

Si Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Oncology

EBNA3C regulates p53 through induction of Aurora kinase B

Hem C. Jha et al.

ONCOTARGET (2015)

Article Oncology

A Cell Biologist's Field Guide to Aurora Kinase Inhibitors

Christian O. de Groot et al.

FRONTIERS IN ONCOLOGY (2015)

Review Biochemistry & Molecular Biology

RASSF tumor suppressor gene family: Biological functions and regulation

Natalia Volodko et al.

FEBS LETTERS (2014)

Article Oncology

Bcr-Abl activates AURKA and AURKB in chronic myeloid leukemia cells via AKT signaling

Jing Yang et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Article Medicine, Research & Experimental

Inhibition of Aurora-B suppresses osteosarcoma cell migration and invasion

Xiao Ping Zhu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2014)

Article Cell Biology

FBXW7 is involved in Aurora B degradation

Chieh-Lin Teng et al.

CELL CYCLE (2012)

Article Oncology

Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells

Kleiton Silva Borges et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2012)

Article Multidisciplinary Sciences

Evolution of Resistance to Aurora Kinase B Inhibitors in Leukaemia Cells

Timothy W. Failes et al.

PLOS ONE (2012)

Article Multidisciplinary Sciences

Aurora B kinase phosphorylates and instigates degradation of p53

Chris P. Gully et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biochemistry & Molecular Biology

Aurora B: A New Prognostic Marker and Therapeutic Target in Cancer

G. Portella et al.

CURRENT MEDICINAL CHEMISTRY (2011)

Article Immunology

AURORA B EXPRESSION AS A PROGNOSTIC INDICATOR AND POSSIBILE THERAPEUTIC TARGET IN ORAL SQUAMOUS CELL CARCINOMA

G. Pannone et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression

Liming Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biotechnology & Applied Microbiology

Comprehensive analysis of kinase inhibitor selectivity

Mindy I. Davis et al.

NATURE BIOTECHNOLOGY (2011)

Article Oncology

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo

Jennifer P. Arbitrario et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)

Article Gastroenterology & Hepatology

The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma

Arihiro Aihara et al.

JOURNAL OF HEPATOLOGY (2010)

Article Chemistry, Medicinal

Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors

Shudong Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Chemistry, Medicinal

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Nicholas D. Adams et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer

Christopher P. Gully et al.

MOLECULAR CANCER (2010)

Article Multidisciplinary Sciences

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

Dun Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization

O. Jameel Shah et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis

Hao G. Nguyen et al.

FASEB JOURNAL (2009)

Article Biochemistry & Molecular Biology

Molecular basis of drug resistance in Aurora kinases

Fiona Girdler et al.

CHEMISTRY & BIOLOGY (2008)

Review Chemistry, Medicinal

Aurora-B Kinase Inhibitors for Cancer Chemotherapy

Sai-Ching Jim Yeung et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)

Article Oncology

FBXW7/hCDC4 is a general tumor suppressor in human cancer

Shahab Akhoondi et al.

CANCER RESEARCH (2007)

Article Pathology

Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme

Weifen F. Zeng et al.

JOURNAL OF CLINICAL PATHOLOGY (2007)

Article Oncology

PHA-680632, a novel aurora kinase inhibitor with potent antitumoral activity

Chiara Soncini et al.

CLINICAL CANCER RESEARCH (2006)

Review Cell Biology

The chromosomal passenger complex: guiding Aurora-B through mitosis

Gerben Vader et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Oncology

Targeting aurora kinases for the treatment of prostate cancer

Edmund Chun Yu Lee et al.

CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation

A Kanda et al.

ONCOGENE (2005)

Article Biochemistry & Molecular Biology

Aurora kinases

VM Bolanos-Garcia

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Mechanism of Aurora B activation by INCENP and inhibition by Hesperadin

F Sessa et al.

MOLECULAR CELL (2005)

Article Endocrinology & Metabolism

Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation

R Sorrentino et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

Review Oncology

Aurora-A - A guardian of poles

T Marumoto et al.

NATURE REVIEWS CANCER (2005)

Article Endocrinology & Metabolism

Aurora B expression in normal testis and seminomas

P Chieffi et al.

JOURNAL OF ENDOCRINOLOGY (2004)

Review Cell Biology

The cellular geography of aurora kinases

M Carmena et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Crystal structure of aurora-2, an oncogenic serine/threonine kinase

GMT Cheetham et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian aurora kinases

C Crosio et al.

MOLECULAR AND CELLULAR BIOLOGY (2002)

Review Cell Biology

Mitotic kinases as regulators of cell division and its checkpoints

EA Nigg

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)