Journal
MOLECULES
Volume 26, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules26061579
Keywords
Sanguisorba officinalis L; herbal medicine; physical performance; LDHA; glycolysis
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT of the Korean Government [2019R1A2C2003624, 2020R1A2C2010964]
- National Research Foundation of Korea [2019R1A2C2003624, 2020R1A2C2010964] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The water-extracted roots of Sanguisorba officinalis L. were found to reduce lactate dehydrogenase A (LDHA) activity and improve physical performance by enhancing AMPKα and PGC-1α levels, while suppressing glycolysis. This suggests that S. officinalis may be a candidate for enhancing physical performance through inhibiting LDHA and glycolysis.
Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of Sanguisorba officinalis L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the S. officinalis-administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPK alpha) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1 alpha) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, S. officinalis might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.
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