Journal
MOLECULES
Volume 26, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules26092594
Keywords
Cassia timoriensis; antioxidant; anti-inflammatory; acetylcholinesterase; Alzheimer
Funding
- USM RU TOP-DOWN project entitled Catalogue of USM-RIKEN Natural Product (CURINaP) Library for the Discovery of Bioactive Molecules on Ageing and Ageing-Related Diseases [1001/PFARMASI/870031]
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This study found that ethyl acetate and methanol extracts of C. timoriensis flowers exhibited the highest antioxidant, anti-inflammatory, and anti-AChE activities, potentially containing bioactive compounds that could be beneficial in controlling neurodegenerative disorders, including Alzheimer's disease.
Despite being widely used traditionally as a general tonic, especially in South East Asia, scientific research on Cassia timoriensis, remains scarce. In this study, the aim was to evaluate the in vitro activities for acetylcholinesterase (AChE) inhibitory potential, radical scavenging ability, and the anti-inflammatory properties of different extracts of C. timoriensis flowers using Ellman's assay, a DPPH assay, and an albumin denaturation assay, respectively. With the exception of the acetylcholinesterase activity, to the best of our knowledge, these activities were reported for the first time for C. timoriensis flowers. The phytochemical analysis confirmed the existence of tannins, flavonoids, saponins, terpenoids, and steroids in the C. timoriensis flower extracts. The ethyl acetate extract possessed the highest phenolic and flavonoid contents (527.43 +/- 5.83 mg GAE/g DW and 851.83 +/- 10.08 mg QE/g DW, respectively) as compared to the other extracts. In addition, the ethyl acetate and methanol extracts exhibited the highest antioxidant (IC50 20.12 +/- 0.12 and 34.48 +/- 0.07 mu g/mL, respectively), anti-inflammatory (92.50 +/- 1.38 and 92.22 +/- 1.09, respectively), and anti-AChE (IC50 6.91 +/- 0.38 and 6.40 +/- 0.27 mu g/mL, respectively) activities. These results suggest that ethyl acetate and methanol extracts may contain bioactive compounds that can control neurodegenerative disorders, including Alzheimer's disease, through high antioxidant, anti-inflammatory, and anti-AChE activities.
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