Polarized SERS Controlled by Anisotropic Growth on Ordered Curvature Substrate

Colloidal lithography is an efficient and low-cost method to prepare an ordered nanostructure array with new shapes and properties. In this study, square-shaped and cone-shaped Au nanostructures were obtained by 70 degrees angle deposition onto polystyrene bead array with the diameter of 500 nm when a space of 120 nm is created between the neighbor beads by plasma etching. The gaps between the units decrease when the Au deposition time increases, which leads to the polarized enhanced local field, in agreement with the surface-enhanced Raman scattering spectra (SERS) observations and finite-difference time-domain (FDTD) simulations. When the Au deposition time increased to 5 min, 5 nm gaps form between the neighbor units, which gave an enhancement factor of 5 x 10(9). The SERS chip was decorated for the detection of the liver cancer cell marker Alpha-fetoprotein (AFP) with the detection limit down to 5 pg/mL.

Automated summary

Colloidal lithography is employed to fabricate square-shaped and cone-shaped Au nanostructures, with control of unit spacing by adjusting Au deposition time to achieve enhanced local field, leading to detection limit down to 5 pg/mL for liver cancer marker AFP.