4.6 Review

Sweet Cherries as Anti-Cancer Agents: From Bioactive Compounds to Function

Related references

Note: Only part of the references are listed.
Article Oncology

Dark Sweet Cherry (Prunus avium) Phenolics Enriched in Anthocyanins Induced Apoptosis in MDA-MB-453 Breast Cancer Cells through MAPK-Dependent Signaling and Reduced Invasion via Akt and PLCγ-1 Downregulation

Marjorie Anne A. Layosa et al.

Summary: This study demonstrated that dark sweet cherry phenolics inhibit the growth and invasion of MDA-MB-453 breast cancer cells by targeting cell signaling pathways that induce apoptosis and suppress cell invasion, with anthocyanins showing enhanced chemopreventive activities.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

Review Chemistry, Medicinal

Revisiting prostate cancer metabolism: From metabolites to disease and therapy

Henrique J. Cardoso et al.

Summary: Prostate cancer metabolism is becoming increasingly important, with metabolic reprogramming and activation of specific pathways playing a crucial role in therapy. Glucose, lipids, and glutamine are essential for PCa cell survival and growth.

MEDICINAL RESEARCH REVIEWS (2021)

Article Oncology

Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation

Henrique J. Cardoso et al.

Summary: The study revealed that androgens play a crucial role in regulating the metabolism of prostate cancer cells, especially in CRPC cells. Inhibition of glutaminolysis with BPTES reduced the viability and migration of PCa cells, with a more significant effect observed in CRPC cells. Targeting glutaminase may offer a promising approach for the treatment of CRPC.

CELLULAR ONCOLOGY (2021)

Review Biochemistry & Molecular Biology

Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis

Kenji Ohshima et al.

Summary: Cancer cells face metabolic challenges at different stages of tumor progression and metastasis, requiring them to reprogram their metabolic state to adapt to changing microenvironments. Metabolic reprogramming is a recognized hallmark of cancer cells and plays a crucial role in supporting cancer growth.

METABOLITES (2021)

Review Biochemistry & Molecular Biology

ROS in cancer therapy: the bright side of the moon

Bruno Perillo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Biochemistry & Molecular Biology

Antitumor potential of dark sweet cherry sweet (Prunus avium) phenolics in suppressing xenograft tumor growth of MDA-MB-453 breast cancer cells

Giuliana Noratto et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

Boris Y. Shorning et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Cherry extracts attenuate inflammation and oxidative stress triggered by monosodium urate crystals in THP-1 cells

Juan Jesus Virgen Gen et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

Review Food Science & Technology

Novel insights in health-promoting properties of sweet cherries

Maria Felicia Faienza et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Endocrinology & Metabolism

Reuniting overnutrition and undernutrition, macronutrients, and micronutrients

Miji Kim et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2019)

Article Food Science & Technology

Bioactivity and cell metabolism of in vitro digested sweet cherry (Prunus avium) phenolic compounds

Serena Martini et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2019)

Review Biochemistry & Molecular Biology

Targeting PI3K in cancer: mechanisms and advances in clinical trials

Jing Yang et al.

MOLECULAR CANCER (2019)

Review Oncology

AKT and ERK dual inhibitors: The way forward?

Zhe Cao et al.

CANCER LETTERS (2019)

Review Chemistry, Medicinal

The peculiarities of cancer cell metabolism: A route to metastasization and a target for therapy

Tiago M. A. Carvalho et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Nutrition & Dietetics

The macronutrients' interplay

M. F. Nassar

CLINICAL NUTRITION (2019)

Article Biochemistry & Molecular Biology

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

Masoud Najafi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Oxidative stress in exercise training: the involvement of inflammation and peripheral signals

Francesca Magherini et al.

FREE RADICAL RESEARCH (2019)

Review Cell Biology

Understanding of ROS-Inducing Strategy in Anticancer Therapy

Su Ji Kim et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Medicine, General & Internal

Inflammation and Cancer

Nitin Singh et al.

ANNALS OF AFRICAN MEDICINE (2019)

Review Neurosciences

Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists

G. Morris et al.

MOLECULAR NEUROBIOLOGY (2018)

Review Nutrition & Dietetics

A Review of the Health Benefits of Cherries

Darshan S. Kelley et al.

NUTRIENTS (2018)

Review Pharmacology & Pharmacy

Oxidative Stress and Cancer

James E. Klaunig

CURRENT PHARMACEUTICAL DESIGN (2018)

Review Public, Environmental & Occupational Health

Inflammation and cancer

Mariko Murata

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE (2018)

Review Pharmacology & Pharmacy

Effects of anthocyanins on the prevention and treatment of cancer

Bo-Wen Lin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Article Agriculture, Multidisciplinary

Characterization of autochthonous sweet cherry cultivars (Prunus avium L.) of southern Italy for fruit quality, bioactive compounds and antioxidant activity

Antonio Di Matteo et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2017)

Article Chemistry, Applied

Comparison of old cherry cultivars grown in Czech Republic by chemical composition and bioactive compounds

Agnieszka Nawirska-Olszanska et al.

FOOD CHEMISTRY (2017)

Article Food Science & Technology

Phenolic compounds profile and antioxidant properties of six sweet cherry (Prunus avium) cultivars

Serena Martini et al.

FOOD RESEARCH INTERNATIONAL (2017)

Article Agriculture, Multidisciplinary

Characterization of Phenolic Compounds from Early and Late Ripening Sweet Cherries and Their Antioxidant and Antifungal Activities

Meng Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Review Oncology

Targeting Inflammation in Cancer Prevention and Therapy

Jelena Todoric et al.

CANCER PREVENTION RESEARCH (2016)

Review Oncology

Significance and therapeutic implications of endothelial progenitor cells in angiogenic-mediated tumour metastasis

Valentina Flamini et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)

Article Food Science & Technology

Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet-induced obese mice

Tao Wu et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

Review Cell Biology

Role of Antioxidants and Natural Products in Inflammation

Palanisamy Arulselvan et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Cell Biology

ROS and ROS-Mediated Cellular Signaling

Jixiang Zhang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Horticulture

Cultivar effect on the sweet cherry antioxidant and some chemical attributes

Jan Skrzynski et al.

FOLIA HORTICULTURAE (2016)

Review Biotechnology & Applied Microbiology

The re-emergence of natural products for drug discovery in the genomics era

Alan L. Harvey et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Review Pharmacology & Pharmacy

Sp1 transcription factor: A long-standing target in cancer chemotherapy

Carolina Vizcaino et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Food Science & Technology

Analytical Methods for Determining Bioavailability and Bioaccessibility of Bioactive Compounds from Fruits and Vegetables: A Review

Juana M. Carbonell-Capella et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2014)

Review Nutrition & Dietetics

Potential Role of Carotenoids as Antioxidants in Human Health and Disease

Joanna Fiedor et al.

NUTRIENTS (2014)

Review Cell Biology

Oxidative stress and cancer: An overview

Venus Sosa et al.

AGEING RESEARCH REVIEWS (2013)

Review Biochemistry & Molecular Biology

21st Century natural product research and drug development and traditional medicines

Linh T. Ngo et al.

NATURAL PRODUCT REPORTS (2013)

Article Medicine, Research & Experimental

Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves

Jonathan Delgado et al.

JOURNAL OF APPLIED BIOMEDICINE (2012)

Article Hematology

Prostaglandins and Inflammation

Emanuela Ricciotti et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Food Science & Technology

Cherries and Health: A Review

Letitia M. McCune et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2011)

Article Chemistry, Applied

Identification of bioactive response in traditional cherries from Portugal

Ana Teresa Serra et al.

FOOD CHEMISTRY (2011)

Review Food Science & Technology

How natural dietary antioxidants in fruits, vegetables and legumes promote vascular health

Sunan Wang et al.

FOOD RESEARCH INTERNATIONAL (2011)

Article Biochemistry & Molecular Biology

Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ

Honghui Guo et al.

JOURNAL OF LIPID RESEARCH (2011)

Review Oncology

Inflammation-mediated promotion of invasion and metastasis

Graziella Solinas et al.

CANCER AND METASTASIS REVIEWS (2010)

Review Oncology

Cancer and metastasis: prevention and treatment by green tea

Naghma Khan et al.

CANCER AND METASTASIS REVIEWS (2010)

Article Geriatrics & Gerontology

Jerte Valley Cherry-Enriched Diets Improve Nocturnal Rest and Increase 6-Sulfatoxymelatonin and Total Antioxidant Capacity in the Urine of Middle-Aged and Elderly Humans

Maria Garrido et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2010)

Review Pharmacology & Pharmacy

COX-2 as a target for cancer chemotherapy

Nilanjan Ghosh et al.

PHARMACOLOGICAL REPORTS (2010)

Article Oncology

Anthocyanins in Black Raspberries Prevent Esophageal Tumors in Rats

Li-Shu Wang et al.

CANCER PREVENTION RESEARCH (2009)

Article Agriculture, Multidisciplinary

Anthocyanin Content, Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Activities of Sweet and Sour Cherries

Vanisree Mulabagal et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2009)

Article Nutrition & Dietetics

Anticancer and Cancer Chemopreventive Potential of Grape Seed Extract and Other Grape-Based Products

Manjinder Kaur et al.

JOURNAL OF NUTRITION (2009)

Article Agriculture, Multidisciplinary

In vitro bioavailability of phenolic compounds from five cultivars of frozen sweet cherries (Prunus avium L.)

Marco Fazzari et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Article Nutrition & Dietetics

Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status

Ronald L. Prior et al.

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2007)

Article Biochemistry & Molecular Biology

Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression

Pei-Ni Chen et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2006)

Review Biotechnology & Applied Microbiology

The evolving role of natural products in drug discovery

FE Koehn et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Oncology

VEGF as a key mediator of angiogenesis in cancer

P Carmeliet

ONCOLOGY (2005)

Article Agriculture, Multidisciplinary

Storage affects the phenolic profiles and antioxidant activities of cherries (Prunus avium L) on human low-density lipoproteins

B Gonçalves et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2004)

Article Cell Biology

Cyanidin and cyanidin 3-O-β-D-glucoside as DNA cleavage protectors and antioxidants

R Acquaviva et al.

CELL BIOLOGY AND TOXICOLOGY (2003)

Article Nutrition & Dietetics

Consumption of cherries lowers plasma urate in healthy women

RA Jacob et al.

JOURNAL OF NUTRITION (2003)

Review Oncology

Role of angiogenesis in tumor growth and metastasis

J Folkman

SEMINARS IN ONCOLOGY (2002)

Article Biochemistry & Molecular Biology

The role of anthocyanins as an antioxidant under oxidative stress in rats

T Tsuda et al.

BIOFACTORS (2000)