Journal
MOLECULAR CELL
Volume 81, Issue 6, Pages 1128-1129Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2021.02.026
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Funding
- Australian Research Council [DP210102704]
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The mechanism identified by Huang et al. stabilizes the interaction of RCC1 with chromatin through the arginine methyltransferase PRMT6, promoting cell proliferation and tumor formation. Targeting this mechanism may improve the treatment of tumors such as glioblastoma.
Huang et al. (2021) identified a mechanism acting through the arginine methyltransferase PRMT6 that stabilizes the interaction of RCC1 with chromatin, promoting cell proliferation and tumorigenicity. Targeting this mechanism might enhance the treatment of tumors such as glioblastoma.
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