Serum G protein-coupled estrogen receptor-1 levels and its relation with death in patients with sepsis: a prospective study

BACKGROUND: The sex hormone estrogen has an immune-supporting role in both trauma and sepsis-related to its immune-modulator role. The aim of the current study was to examine the prognostic role of (serum G Protein-coupled estrogen receptor-1) GPER-1 in sepsis and sepsis-related mortality. METHODS: Prospective evaluation was made of the data on a total 160 patients followed-up in the Intensive Care Unit because of sepsis. Patients were separated into two groups as survivor and non-survivor group. The Sequential Organ Failure Assessment (SOFA) Score, APACHE II Score and Charlson Comorbidity Index (CCI) were calculated for each patient. Serum GPER-1 levels were evaluated for each patient. RESULTS: Compared with non-survivors, the surviving patients were determined with significantly higher levels of PLT, CRP, GPER-1, SOFA, and APACHE II scores. The GPER-1 levels showed a significant positive correlation with CRP levels, SOFA, and APACHE II scores. ROC curve analysis demonstrated 85.7% sensitivity and 72.1% specificity of GPER-1 to predict 28-day mortality. GPER-1 and APACHE II scores were determined to be an independent prognostic factor for predicting mortality. CONCLUSIONS: Serum GPER-1 can be used as a new prognostic factor for survival in patients diagnosed with sepsis.

Automated summary

This study found that serum GPER-1 levels are closely associated with the prognosis of sepsis patients, with higher GPER-1 levels being linked to better outcomes. GPER-1 and APACHE II scores can independently predict mortality in sepsis patients.