4.7 Article

Carboxylated single-wall carbon nanotubes decorated with SiO2 coated-Nd2O3 nanoparticles as an electrochemical sensor for L-DOPA detection

Journal

MICROCHEMICAL JOURNAL
Volume 168, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.microc.2021.106416

Keywords

Amperometry; Electrochemical sensing; L-DOPA; Nanostructure; SWCNT-COOH@Nd2O3-SiO2

Funding

  1. Ministry of Education, Science and Technological Development of Republic of Serbia [451-03-9/2021-14/200168, 451-03-9/2021-14/200026]
  2. CEEPUS network [CIII-CZ-0212-13-1920-M-131892]
  3. Education of Modern Analytical and Bioanalytical Methods

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L-DOPA, a precursor of dopamine used in Parkinson's disease treatment, requires accurate concentration monitoring. This study presents the development of an electrochemical sensor using carboxylated single-wall carbon nanotubes decorated with SiO2 coated-Nd2O3 nanoparticles for L-DOPA detection. The sensor shows linear response, low detection limit, fast response time, and good reproducibility in detecting L-DOPA concentration.
L-DOPA (L-3,4-dihydroxyphenylalanine), the precursor of dopamine, is widely used in the treatment of Parkinson's disease, thus determining and monitoring the concentration of L-DOPA is of utmost importance for both medical and scientific purposes. Although many analytical approaches, designed for drug detection and quantification, already exist, there is a constant need for modification of old and tailoring of new, faster, and selective methods. Redox active chemical species, such as L-DOPA, can be measured directly by electrochemical means, whereas electrochemical sensors combine sensitivity and selectivity within a small analytical device. This work demonstrates the development of such electrochemical sensor, based on carboxylated single-wall carbon nanotubes (SWCNT-COOH) decorated with SiO2 coated-Nd2O3 nanoparticles, and further application for the detection of L-DOPA. Developed SWCNT-COOH@Nd2O3-SiO2 sensor shows linear response in the range from 2 mu mol L-1 to 52 mu mol L-1 analyte concentration, and beside the low detection limit, it is characterized by a fast response time, as well as good life-time, reproducibility and repeatability.

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