Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 124, Issue -, Pages 1019-1025Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2016.10.034
Keywords
Antimicrobial; Naphthoquinones; Staphylococcus aureus; Haemolysis
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Funding
- Polish National Science Centre [2012/05/B/ST5/00362]
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Naphthalene-1,4-dione derivatives were synthesized and tested against selected bacterial strains. All the tested compounds were prepared by direct introduction of corresponding substituents into the naphthoquinone core in oxidative conditions. In this study, eight strains of bacteria (Proteus, Escherichia, Klebsiella, Staphylococcus, Enterobacter, Pseudomonas, Salmonella, Enterococcus) were used for determination of antimicrobial activity of synthesized compounds with the Minimal Inhibitory Concentration (MIC) method. Additionally, selected compounds were tested for haemolytic activity using human erythrocytes. All naphthalene-1,4-dione derivatives exhibited significant antimicrobial activity with MIC values between 7.8 and 500 mu g/ml. A majority of the synthesized compounds showed the strongest antibacterial properties towards S. aureus, with a high level of selectivity. None of the tested naphthalene-1,4-dione derivatives exhibited haemolytic activity. (C) 2016 Elsevier Masson SAS. All rights reserved.
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