His bundle pacing therapy for patients with chronic heart failure A protocol for meta-analysis based on prospective studies

Introduction: A considerable amount of studies have been published with the results of clinical benefit from his bundle pacing (HBP) for chronic heart failure (CHF) patients and these researches led a uncertain conclusion for clinics. Thus, we will conduct a meta-analysis to evaluate the effect of his bundle pacing therapy for chronic heart failure. Methods: Pubmed, EMBASE, the Cochrane Library, Web of Science and Chinese online databases including Chinese National Knowledge Infrastructure, China Biology Medicine disc, Chinese Scientifific Journals Database (VIP), and Wanfang Database will be searched from these databases construction to the end of November, 2020. The STATA 13.0 will be used for data synthesis and meta-analysis. Results: The outcome measures included QRS duration, left ventricular ejection fraction, pacing threshold, New York Heart Association (NYHA), left ventricular end-diastolic diameter, left ventricular end-systolic diameter, mitral regurgitation, tricuspid regurgitation, and BNP will be analyzed and synthesized. Conclusion: This meta-analysis will evaluate the effect of his bundle pacing therapy for chronic heart failure. Registration number: INPLASY202110109.

Automated summary

This study aims to evaluate the effect of His bundle pacing therapy for chronic heart failure through meta-analysis, analyzing outcomes such as QRS duration, left ventricular function, and heart failure severity.